NIH and CDC Release Solicitation For Contract Proposals

The SBIR contracts solicitation of the National Institutes of Health (NIH) and The Centers for Disease Control and Prevention (CDC) (PHS-2025-1) has been released.

If you want to submit a proposal, please review the specific need areas (Contract Topics). Your proposal must respond to one of these topics listed in the solicitation.

THE FOLLOWING RESEARCH TOPICS ARE ANTICIPATED TO BE INCLUDED IN SBIR CONTRACT SOLICITATION PHS-2025-1

NATIONAL INSTITUTES OF HEALTH (NIH)

NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES (NCATS):

• Topic 025        Development of a versatile small footprint benchtop device to perform batch evaporation
• Topic 026        Scalable Generation of Liver and Brain Organoids Derived from Human iPS Cells.

NATIONAL CANCER INSTITUTE (NCI):

• Topic 466        Novel Delivery Systems for RNA-based Cancer Vaccines
• Topic 467        Development of Cancer Immunoprevention Agents
• Topic 468        Synthetic Microbes (Excluding Oncolytic Viruses) for Immuno-Oncology Therapies
• Topic 469        Development of Novel Therapeutics for HPV-related Precancer
• Topic 470        Precision Nutrition Interventions to Reduce Cancer-Related Symptoms
• Topic 471        Drug-Loaded Carrier Particles for Improved Oral Delivery for Colon Cancer Prevention
• Topic 472        Antibody-Drug Conjugates as Radiopharmaceutical Theranostics for Cancer
• Topic 473        Point of Care Detection of Antibodies Against HPV16/18 E6 and E7 Oncoproteins in Oropharyngeal Cancer
• Topic 474        Point of Care Technologies for GI Cancer Prevention and Early Detection
• Topic 475        Development of Digital Biomarkers and Endpoints for Clinical Cancer Care
• Topic 476        Digital Twin Software for Optimization of Cancer Radiation Therapy
• Topic 477        Wearable Technologies to Facilitate Remote Monitoring of Cancer Patients Following Treatment
• Topic 478        Advanced Biomaterials to Improve Cancer Modeling for Research

NATIONAL INSTITUTE ON AGING (NIA):

• Topic 011        Digital Technologies as Tools to Screen and Monitor Alzheimer’s Disease (AD) and Related Dementias (ADRD)
• Topic 012        Modeling Aging through Microphysiological Systems
• Topic 013        Leveraging Multimodal and Generative Artificial Intelligence to Advance the Application of Social Robotics in Caregiving

NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

• Topic 020        Alcohol-activated locking systems for firearms and firearm storage units
• Topic 021        Data science tools for accelerating alcohol research
• Topic 022        Non-invasive Wearable Alcohol Sensor

NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (NIAID):

• Topic 137        New Drug Classes with Novel Mechanisms of Action for HIV, Hepatitis B, and Tuberculosis
• Topic 138        Devices and Materials-Based Platforms for the Delivery of Broadly Neutralizing Antibodies
• Topic 139        Rapid Diagnostic Assays for Self-Monitoring of Acute or Rebound HIV-1 Infection
• Topic 140        Adjuvant Discovery and Down-Selection for Vaccines against Infectious and Immune-Mediated Diseases
• Topic 141        Reagents for Immunologic Analysis of Non-mammalian and Underrepresented Mammalian Models
• Topic 142        Adjuvant Development for Vaccines and for Autoimmune and Allergic Diseases
• Topic 143        Development of Diagnostics for Mycoplasma genitalium Infection
• Topic 144        Development of Medical Interventions for Treating Non-Tuberculosis Mycobacterial (NTM) Infections
• Topic 145        Diagnostics to Detect Host Immunity to Coccidioidomycosis (Valley fever) or Histoplasmosis
• Topic 146        Discovery and Development of Oral Small-molecule Direct-acting Antivirals Targeting Viruses of Pandemic Potential
• Topic 147        Software or Web Services to Assess Quality and Reproducibility of Data and Information about Therapeutics and Vaccines

NATIONAL INSTITUTE OF MENTAL HEALTH (NIMH):

• Topic 001        Point-of-Care and Pharmacy-based Antiretroviral Drug Adherence Assays
• Topic 002        Development of novel In-vitro and In-vivo Models to support NeuroHIV Research

CENTERS FOR DISEASE CONTROL AND PREVENTION (CDC)

NATIONAL CENTER FOR EMERGING ZOONOTIC AND INFECTIOUS DISEASE (NCEZID):

• Topic 032        Canine Vaccines to Prevent Tick Bites
• Topic 033        Rapid, Portable, Point-of-Care Carbapenem Resistant Acinetobacter Colonization Screening Diagnostic
• Topic 034        Improved Diagnostic Assays for Foodborne and Waterborne Bacterial Pathogens
• Topic 035        Improved Diagnostic Assays for Parasitic Diseases
• Topic 036        Developing an Over-the-Counter Diagnostic for Valley Fever
• Topic 037        Enhancing the CDC Autocidal Gravid Ovitrap to Control Dengue Vectors

NATIONAL CENTER FOR IMMUNIZATION AND RESPIRATORY DISEASES (NCIRD):

• Topic 038        Development of a Molecular Panel to Detect Febrile Rash Illnesses
• Topic 039        Synthetic IgM Antibody Controls for Measles, Mumps, and Rubella Assays

NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL (NCIPC)

• Topic 001        Data Science Solutions to Characterize Polysubstance Use Behavior from Online Sources

SBIR and STTR grant opportunities are also available for investigator-initiated ideas. Companies are encouraged to review omnibus SBIR/STTR grant solicitations of the National Institutes of Health, Centers for Disease Control and Prevention and Food and Drug Administration posted on the NIH SBIR/STTR funding web page located at https://seed.nih.gov/small-business-funding/find-funding/sbir-sttr-funding-opportunities#omnibus-solicitations.

Standard due dates for SBIR/STTR grant applications are September 5th, January 5th, and April 5th. To understand better the differences between grants and contracts, see https://seed.nih.gov/apply.