NIH

  • NIH Policy Updates 2026

    Standard Application Due Dates are September 5, January 5, and April 5. Due dates that fall on weekends or Federal holidays are moved to the next business day.

    The next upcoming due date is September 8, 2026.

    Website: https://seed.nih.gov/

    Overview: As part of the Department of Health and Human Services, NIH funds biomedical and health-related research, aiming to enhance health and reduce illness.​

    Funding Focus Areas: Biomedical research, healthcare innovations, medical devices.​

    Funds health, life science, and biomedical discoveries that could impact the lives of patients and their families

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  • Required Registrations
    Applicant organizations must complete and maintain the following registrations as described in the How to Apply – Application Guide to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. Failure to complete registrations in advance of a due date is not a valid reason for a late submission, please reference NIH Grants Policy Statement 2.3.9.2 Electronically Submitted Applications for additional information.

    • System for Award Management (SAM) – Applicants must complete and maintain an active registration, which requires renewal at least annually. The renewal process may require as much time as the initial registration. SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code.
    • Unique Entity Identifier (UEI) – A UEI is issued as part of the SAM.gov registration process. The same UEI must be used for all registrations, as well as on the grant application.
    • SBA Company Registry – See How to Apply – Application Guide for instructions on how to register and how to attach proof of registration to your application package. Applicants must have a UEI to complete this registration. SBA Company registration is NOT required before SAM, Grants.gov or eRA Commons registration.
    • eRA Commons – Once the unique organization identifier is established, organizations can register with eRA Commons in tandem with completing their Grants.gov registration; all registrations must be in place by time of submission. eRA Commons requires organizations to identify at least one Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account in order to submit an application.
    • Grants.gov – Applicants must have an active SAM registration in order to complete the Grants.gov registration.

    Funding Opportunity Goal(s)
    NIH's mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability.

    The goals are:

    • to foster fundamental creative discoveries, innovative research strategies, and their applications as a basis for ultimately protecting and improving health;
    • to develop, maintain, and renew scientific human and physical resources that will ensure the Nation's capability to prevent disease;
    • to expand the knowledge base in medical and associated sciences in order to enhance the Nation's economic well-being and ensure a continued high return on the public investment in research; and
    • to exemplify and promote the highest level of scientific integrity, public accountability, and social responsibility in the conduct of science.

    In realizing these goals, the NIH provides leadership and direction to programs designed to improve the health of the Nation by conducting and supporting research:

    • in the causes, diagnosis, prevention, and cure of human diseases;
    • in the processes of human growth and development;
    • in the biological effects of environmental contaminants;
    • in the understanding of mental, addictive and physical disorders; and
    • in directing programs for the collection, dissemination, and exchange of information in medicine and health, including the development and support of medical libraries and the training of medical librarians and other health information specialists.
    Title Notice/FOA Number Organization Release Date Due Date(s) Expiration Date Clinical Trials
    NIH Small Business Innovation Research (SBIR) Phase IIB Strategic Breakthrough Award (Parent [R44] Clinical Trial Optional) PA-27-101 NIH 05/28/2026 04/06/2029 Optional
    NIH Small Business Technology Transfer Grant (Parent STTR [R41/R42] Clinical Trial Optional) PA-27-102 NIH 05/28/2026 04/06/2027 Optional
    NIH, CDC and FDA Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Optional) PA-27-100 NIH 05/28/2026 04/06/2027 Optional
    SBIR/STTR Commercialization Readiness Pilot (CRP) Program (Parent SB1 Clinical Trial Optional) PAR-27-098 OD 05/28/2026 04/06/2027 Optional

8 files
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2024-25 HHS Program Descriptions.pdf
1.85 MB
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2024 HHS Topics for Budget Waivers.pdf
375.9 KB
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2021-2025 NIH Strategic Plan 508.pdf
7.07 MB
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Deciphering_NIH_Application.pdf
94.88 KB
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2024-2028 ORWH NIH Wide Strategic Plan-508C.pdf
9.17 MB
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Required Company Registrations.pdf
165.52 KB
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eRA Commons Roles & Privileges Matrix
91.14 KB
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ASSIST_User_Guide.pdf
20.25 MB
360 360 MNSBIR Inc.
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