• Approved

• SAM
• GRANTS
• eBRAP

(1) Clinical Trial Award (2) Investigator-Initiated Research Award (3) Translational Research Award

The FY26 Defense Appropriations Act provides funding for the TERP to support innovative, high-impact research with clinical relevance that will improve the health and quality of life and mitigate risks for those impacted by military-related toxic exposures. As part of the DHA R&D-MRDC, the CDMRP is the program office managing these anticipated FY26 funding opportunities.

The TERP provides the information in this pre-announcement to allow investigators time to plan and develop ideas for submission to the anticipated FY26 funding opportunities. Investigators should not construe this pre-announcement as an obligation or promise by the government. The CDMRP will post FY26 TERP funding opportunity announcements on the Grants.gov website. Once released, the funding opportunity announcements will include pre-application and application deadlines.

Applications submitted to the FY26 TERP must address one or more of the following program goals:

The program does not list program goals in order of importance. The TERP provides bulleted items for additional context on current program priorities. While encouraged, the TERP does not require applicants to specifically address bulleted items.

Predict and prevent: Identify strategies that can anticipate, identify, monitor and prevent adverse effects of exposures to toxic substances, such as:

Understand the full range of effects from military-related environmental and toxic exposures
Understand the mechanisms of multigenerational effects of military-related toxic exposures and the impact of these exposures on reproductive health
Identify biological and/or psychosocial variables and risk factors that can impact disease outcomes from toxic exposures
Develop, adapt, validate or optimize monitoring; for example, personal devices and individual environmental exposures
Diagnose: Understand the clinical signs, symptoms and outcomes associated with exposures, and predict disease progression to develop specific or improved diagnostics, such as:

Understand complex, multi-exposure/physiological or non-chemical stressor combinations and how exposure impacts outcome; examples of stressors include hormonal, sleep disorders and thermal stress
Identify behavioral factors, such as smoking, substance abuse, etc.; comorbidities; and preexisting medical conditions that may impact exposure outcomes
Identify biomarkers of exposure to individual or multiple toxic substances alone or in combination with physiological/non-chemical stressors
Develop diagnostic screens/assays/devices for toxic exposures
Treat: Minimize symptoms and disease progression associated with exposures, such as:

Develop new or improve existing therapeutics, treatments and strategies
Advance new therapeutics, treatments and strategies
Address the need for preclinical models that capture the adverse outcomes of human toxic exposures
Applications submitted to the FY26 TERP must address at least one of the following topic areas:

The TERP does not list topic areas in order of importance.

Neurotoxin Exposure
Gulf War Illness and Its Treatment
Airborne Hazards and Burn Pits
Other Military Service-Related Toxic Exposures in General, Including Prophylactic Medications, Pesticides, Organophosphates, Toxic Industrial Chemicals, Materials, Metals and Minerals